Clinical References Utilizing a Sealant


Cyanoacrylate microbial sealants for skin preparation prior to surgery

Wood C, Phillips C

"In this second update there is still insufficient evidence available to determine whether the use of microbial sealants reduces the risk of surgical site infection or not. Further rigorous, adequately-powered RCTs are required to investigate this properly."

Reducing morbidity with surgical adhesives following inguinal lymph node dissections for the treatment of malignant skin tumors

Stollwerck PL, Schlarb D, Münstermann N, Stenske S, Kruess C, Brodner G, Krapohl BD, Krause-Bergmann AF

"The use of TissuGlu in our ILND patients was associated with a reduction in post-operative wound related complications and the need for revision surgeries compared to the control group. Daily drainage was significantly lower within the first 7 post-operative days with the use of ARTISS, but the benefit was lost due to the higher occurrence of wound infection and revision surgery. BMI above 29 is a risk factor for complications following ILND."

Octyl-2-cyanoacrylate adhesive for skin closure: Eight years experience

Grimaldi L, Cuomo R, Brandi C, Botteri G, Nisi G, D'Aniello C

"Octyl-2-cyanoacrylate is a valuable aid for ensuring the success of surgery by reducing surgical site infections. The use of octyl-2-cyanoacrylate is easy, guarantying a major superficial protection without relevant contraindications and with evident saving of time and resources."

Influence of preoperative skin sealing with cyanoacrylate on microbial contamination of surgical wounds following trauma surgery: A prospective, blinded, controlled observational study

Daeschlein G, Napp M, Assadian O, Bluhm J, Krueger C, von Podewils S, Gümbel D, Hinz P, Haase H, Dohmen PM, Koburger T, Ekkernkamp A, Kramer A

"Preoperative sealing reduced microbial contamination on sutures during surgery, while the overall wound contamination remained unchanged. Hence, prevention of the clinically more relevant deep SSIs may not be expected. However, this study was not designed to detect differences in the rate of SSI. The role of the reduction in suture contamination with regard to the prevention of SSI remains to be evaluated."

Bacterial growth and wound infection following saphenous vein harvesting in cardiac surgery: A randomized controlled trial of the impact of microbial skin sealant

Falk-Brynhildsen K, Söderquist B, Friberg O, Nilsson U

"We found almost no intraoperative bacterial presence on the skin or in the subcutaneous tissue, irrespective of microbial skin sealant use. In contrast, we observed a relatively high incidence of late wound infection, indicating that wound contamination occurred postoperatively. Further research is necessary to determine whether the use of microbial skin sealant reduces the incidence of leg wound infection at the saphenous vein harvest site."

Efficacy of Integuseal for Surgical Skin Preparation in Children and Adolescents Undergoing Scoliosis Correction

Dromzee E, Tribot-Laspière Q, Bachy M, Zakine S, Mary P, Vialle R

A prospective randomized trial of 56 patients (28 with Integuseal and 28 without Integuseal) found that although microbial sealant may be a useful addition to a multimodal approach to minimize surgical site infection, there is currently insufficient evidence as to whether the use of microbial sealants reduces the risk of surgical site infection in patients undergoing scoliosis surgery.

A Randomized Trial of a Skin Sealant to Reduce the Risk of Incision Contamination in Cardiac Surgery

von Eckardstein AS, Lim CH, Dohmen PM, Pêgo-Fernandes PM, Cooper WA, Oslund SG, Kelley EL

A randomized, controlled, parallel-group, multicenter, open-label clinical trial including 300 coronary artery bypass graft surgery patients concluded that pretreatment of the skin with a sealant protects against contamination of the surgical incision by migration of skin microbes.

Reduction of surgical site infection using a microbial sealant: A randomized trial

Iyer A, Gilfillan I, Thakur S, Sharma S

A prospective, randomized, controlled clinical trial of patients undergoing coronary artery bypass grafting was terminated after the review of 47 patients exemplified that use of a microbial sealant immediately before the incision significantly reduced the rate of SSI compared to the conventional skin preparation.

A retrospective non-randomized study on the impact of INTEGUSEAL, a preoperative microbial skin sealant, on the rate of surgical site infections after cardiac surgery

Dohmen PM, Gabbieri D, Weymann A, Linneweber J, Geyer T, Konertz W

A retrospective non-randomized study involving 580 patients undergoing cardiac surgery determined that preoperative use of a microbial skin sealant in addition to standard preoperative preparation significantly reduces the surgical site infection rate.

Cyanoacrylate microbial sealants for skin preparation prior to surgery

Lipp A, Phillips C, Harris P, Dowie I

A review of randomized controlled trials determined that one small trial showed no statistically significant difference in the rates of surgical site infection with the use of cyanoacrylate microbial sealants for skin preparation. Further rigorous randomized controlled trials are required.

Microbial sealing: a new approach to reducing contamination

Wilson SE

An in-vitro study including 177 patients undergoing open, clean, inguinal hernia repair found that microbial sealing, as compared to povidone iodine alone, significantly reduces surgical wound bacterial contamination when used in conjunction with 10% povidone iodine skin preparation.

Significant Reduction in Incidence of Wound Contamination by Skin Flora Through Use of Microbial Sealant

Towfigh S, Cheadle WG, Lowry SF, Malangoni MA, Wilson SE

A prospective, randomized, multicenter clinical trial involving 177 patients undergoing elective open inguinal hernia repair determined that cyanoacrylate-based microbial sealant may be an important tool in reducing the incidence of wound contamination and consequently reducing surgical site infections.

A review of current strategies to reduce intraoperative bacterial contamination of surgical wounds

Dohmen PM, Konertz W

The article reviews current strategies to reduce intraoperative bacterial contamination of surgical wounds and introduces a pilot study of 350 patients undergoing cardiac surgery. Although data was not statistically significant, the preliminary results were promising, showing a trend in reducing surgical site infection by using a microbial sealant in addition to common surgical skin preparation.

Research Studies Utilizing a Sealant