In Vivo and in Vitro Antibacterial Efficacy of PDS Plus (Polidioxanone with Triclosan) Suture
A study on the efficacy of polydioxanone suture with and without triclosan against gram-positive and gram-negative bacteria was conducted in vitro by zone of inhibition assays and in vivo on guinea pigs and mice. In vitro, polydioxanone suture with triclosan had activity against S. aureus, MRSA, E. coli, S. epidermidis, MRSE, and K. pneumoniae. In vivo, triclosan inhibited colonization of the suture by S. aureus and E. coli. The study concluded that polydioxanone suture with triclosan may be useful in risk reduction of surgical site infection caused by susceptible bacteria.